Codeweavers (
http://www.codeweavers.com ) have a modification of Wine desgned to run MS Office, but it's not free and you're supposed to be able to get Office to work also under the normal Wine (but maybe with a few more headaches

).
But if you also want games I suggest you try out WineX from Transgaming. WineX isn't free if you want the prebuilt binary RPMs, but you can still get it from their CVS repository and compile it from there (the CVS version lacks support for some copy protection in games though).
Have fun.